Chemo (BDC Concepts)
07-17-2004, 09:28 PM
The putative pheromone androstadienone activates cortical fields in the human brain related to social cognition.
Gulyas B, Keri S, O'Sullivan BT, Decety J, Roland PE.
Department of Neuroscience, Karolinska Institute, S-171 77 Stockholm, Sweden. balazs.gulyas@neuro.ki.se
Abstract:
Using 15O-butanol positron emission tomography (PET), we measured regional cerebral blood flow changes in five healthy young women during exposure to androstadienone, a putative human pheromone, as well as pleasant (gamma-methyl-ionone), unpleasant (methyl-thio-butanoate), and neutral (dipropylene glycol; vehicle compound) odours. Compared with the odorous substances, androstadienone activated a widely distributed neuronal network. Two large cortical fields exhibited consistent activation in each contrast: the anterior part of the inferior lateral prefrontal cortex (PFC) and the posterior part of the superior temporal cortex (STP). Intriguingly, these areas were deactivated by gamma-methyl-ionone and methyl-thio-butanoate. These brain regions can be identified as cortical fields underlying other than olfactory functions, including various aspects of social cognition and attention.
I don't know if these articles have been posted before so someone feel free to delete these if redundant.
Looks like dienone may hold promise ;)
Bobby
Discussion on this topic can be found by clicking here. (http://love-scent.com/forum/showthread.php?t=10921)
Gulyas B, Keri S, O'Sullivan BT, Decety J, Roland PE.
Department of Neuroscience, Karolinska Institute, S-171 77 Stockholm, Sweden. balazs.gulyas@neuro.ki.se
Abstract:
Using 15O-butanol positron emission tomography (PET), we measured regional cerebral blood flow changes in five healthy young women during exposure to androstadienone, a putative human pheromone, as well as pleasant (gamma-methyl-ionone), unpleasant (methyl-thio-butanoate), and neutral (dipropylene glycol; vehicle compound) odours. Compared with the odorous substances, androstadienone activated a widely distributed neuronal network. Two large cortical fields exhibited consistent activation in each contrast: the anterior part of the inferior lateral prefrontal cortex (PFC) and the posterior part of the superior temporal cortex (STP). Intriguingly, these areas were deactivated by gamma-methyl-ionone and methyl-thio-butanoate. These brain regions can be identified as cortical fields underlying other than olfactory functions, including various aspects of social cognition and attention.
I don't know if these articles have been posted before so someone feel free to delete these if redundant.
Looks like dienone may hold promise ;)
Bobby
Discussion on this topic can be found by clicking here. (http://love-scent.com/forum/showthread.php?t=10921)