Androstadienone Ineffective If VNO Is Blocked

[DrSmellThis]

DST: If you want

the .pdf of the article at the URL below, I will need your current email address.



http://

www.haworthpress.com/store/ArticleAbstract.asp?sid=F1AJ71WMKCP48HTMPW51HDT2GP 7Q5DS7&ID=90566





Isolation of the VNO was initially linked to a patented process/delivery system as I recall. This was seen by many

researchers to be a 2nd red flag with regard to findings that could not be independently replicated on picogram

amounts of "active" compounds.

In the most recently reported published findings: "Thirty milligrams of AND...,

were deposited in pure form into a 60ml... opaque jar, to be smelled by participants."

From a human VNO

activation to effect approach, it's picogram amounts and unreplicated data. From the more current non-VNO approach

we're seeing effects with (let me check my math... uh?) -- a lot more of the compound.

It's hard for me to

imagine any woman ever being naturally exposed to 20 sniffs of 30 milligrams of AND. So, while it's good to see

reports of hormonal, mood, and arousal change, I'm not sure how all this translates to product development.



Seems we've now gone from activating the VNO with picogram amounts of AND, blocking the VNO and showing that it

makes a difference (though the data may not be published or replicated) and finally come round to attacking the

human olfactory/pheromonal processing system (sans VNO mention?) with massive doses of chemical.

James V.

Kohl
author of a less recent review at:

http://www.nel.edu/22_5/NEL220501R01_Review.htm

* I'm interested specifically mainly in just in reviews of the VNO studies. I realize there isn't that much out

there. Unfortunately, most of it was behind closed doors.

* I didn't see anything in the abstract about dosage.

You'd think they'd vary it. It's not hard methodologically. You wouldn't even need more subjects.

* The

problem of isolating the VNO in this study is different that was addressed by Erox's patented delivery and

measurement methods, if that's what you are referring to. The procedures are very different.

* I just think the

disinterest problem is that the VNO is correctly thought of as a secondary issue, compared to the importance of

pheromones for humans in general; and researchers have more basic questions for now. That to me explains the lack of

interest. In the big picture, human pheromone research is still in the infantile stage.

* Obviously, that reason

for disinterest doesn't apply to the Erox gang, who apparently believe worlds of Exxon-like profits await them if

they focus on the VNO.