J Kohl what about "sniff and sex"PT-141

[**DONOTDELETE**]

hi,

I was wondering what your opinion of this product is. Its on your web site and I was wondering if you had any info on this product as to when it will be available etc.

Thanx [img]images/icons/smile.gif[/img] http://www.ananova.com/news/story/sm_434694.html

[ April 23, 2002: Message edited by: vortex ]

[**DONOTDELETE**]

Where did you find the word \"plump\"? I found plumb, but no plump. Am I missing something?

[camusflage]

Interesting.. Quite interesting. It\'s not a phero, as the info (and the acronym) says it\'s a peptide, so it\'s a protein of some sort. The nasal application is most likely because of the ease of application and the speed with which it passes through the mucous membranes without having to stand up to the acids in the stomach.

On the subject of application.. There\'s now a creme that has the same drug in it that had previously been injected in the <ahem> equipment to get it up. Now, I wonder why the injection didn\'t meet with mass-market success. [img]images/icons/smile.gif[/img]

[Whitehall]

Sounds like this sniff stuff is oxytocin or a variant thereof; maybe apomorphine.

Anyone else care to guess?

[jvkohl]

Their approach is not pheromonal:

PT-141 is a peptide analog of a-MSH (a-melanocyte-stimulating hormone). Scientists have determined that
receptors for this class of molecules (melanocortin receptors) play a role in several behaviors, including sexual
arousal and appetite. Recent findings indicate the effects on sexual function may be stimulated through
melanocortin receptors in the brain. As a result, Palatin believes PT-141 has the potential to offer a unique
treatment for both male and female sexual dysfunction.

Simply put, intranasal delivery is a route for administration that has created significant interest in recent years. This gets drugs into our system with minimal side effects and no invasive techniques (like injections).

[Bruce]

OOPS... goofed on the plumbing. It was late.

Is this stuff likely to be over the counter or prescription only?

Bruce

[jvkohl]

Over the counter drugs like this are typically only available 1) after the initial patent expires 2) after a variety of generics have generated sufficient sales 3 after the FDA determines there can be virtually no major negative side effects.

You may see this as an over the counter drug, but not until long after Viagra, Prozac, etc. are available (if ever) over the counter.

[Bruce]

That looks interesting. What the heck is that stuff? Notice the use of the word \"plump\" in the article. :0) Oh, those whacky scientists.

Bruce

[xvs]

Anyone want to take the plunge?

Biotinyl-Alpha-Melanocyte Stimulating Hormone
SEQUENCE: Biotin-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

CAT. No.7266
0.1mg* $180.00
0.5mg* $540.00

too rich for my blood...

[Whitehall]

OK, how many NANOgrams for a dose?

[jvkohl]

Careful with your money folks; as I recall \"peptide analog\" means there is no way we can no what the sequence is in PT-141. So even if we could afford to experiment, good results would be unlikely.

[xvs]

Hmm.... you think it\'s an analog but one that\'s stronger than the real thing? That could be the case.

Wouldn\'t the real thing have some activity though? Maybe the analog is just a lot cheaper to make?

[jvkohl]

The analog could be much more effective; no way to tell whether the original sequence would be more or less effective-if effective at all. Typically though, it is more expensive to produce the analog compared to the original substance--since chemical alteration of the original often is required.