phenomenally pheromonal molecular
hybrid hypothesis
PREFACE: Hello, I'm the archetypical hybrid
(HEC):wave:
I'm a student majoring in neuropharmacology, organic chemistry, chemical &
mechanical engineering, and I'm conducting some private research on phenomenal pheromones as described
hereafter.
For your referances:
androsta-4,16-dien-3-one =
androstadienone
5α-androstan-3-one =
androstAnone
5α-androst-16-en-3-one = androstenone
4-androsten-3-one
= 4-androstenone
Based upon the quantitative structure-property relationships I've studied for
steroids which are active at the human female VNO, I believe that 4-ANDROSTEN-3-ONE (DESOXYTESTOSTERONE), may be
very active at the human female VNO. This hypothesis is derived from the fact that only two pheromones:
androsta-4,16-dien-3-one, and 5α-androstan-3-one are significantly active at the human female
VNO [as substantiated by an Erox study long ago titled: the sixth sense].
5α-androstan-3-one is a saturated analogue of 5α-androst-16-en-3-one (a pig
pheromone), which has an alkene group at the 16th carbon of the prototypical skeletal molecule.
5α-androst-16-en-3-one does not target the human female VNO, whereas
5α-androstan-3-one does; the only difference being the alkene group at the 16th carbon. Now,
androsta-4,16-dien-3-one, an analogue of 5α-androst-16-en-3-one is very active at the human
female VNO, the only difference between the two being an alkene group at the 4th carbon.
http://www.direct.com/images/pheromone%20SAR.JPG
From logical deduction and
quantitative structure-property relationships, I assert the following:
A) An alkene group at the 3rd carbon of
the skeletal molecule dramatically increases activity at the VNO
B) A fully saturated group at the 16th-17th
carbons also significantly increases activity.
EPILOGUE: Therefore, it is my hypothesis that
4-androsten-3-one, as a molecular hybrid containing the most desired substitutions may be very active at the human
female VNO, more so than the archetypical androsta-4,16-dien-3-one. If possible I ask for you good folks within this
esoteric paradigm to voice your opinion with respect to this hypothesis.:think:
Estrenes for inducing hypothalamic effects
@Archetypical Hybrid (HEC)
Would Vomeropherins A, C, D, E12/N1 & E8/N1 be useful for males?
How do I find the trivial names & CAS no. of the chemicals (if they do exists)?
Thanks.
i2w
Estrenes for inducing hypothalamic
effects
[url]http://www.freepatentsonline.com/5633392.html?s_id=25a1612519fd658844968b63e6f1d01c[/url
]
BLUE = pro-males
RED =
pro-females
A = 1, 3, 5(10),16-Estratetraen-3-yl acetate
B = Androsta-4,16-dien-3-one (i.e. A1) [VNO-1
]
C = 1,3,5(10),16-Estratetraen-3-ol (i.e.
EST)
D = 3-Methoxy-Estra-1,3,5(10),16-tetraene
E =
Androsta-4,16-dien-3.alpha.-ol
F = Androsta-4,16-dien-3.beta.-ol
G =
Androst-4-en-3-one
H = Androsta-4,16-diene-3,6-dione
J = 10,17-Dimethylgona-4,13(17)-dien-3-one
K =
1,3,5(10),16-Estratetraen-3-ol-methyl ether [E0723-080 Steraloids]
L =
1,3,5(10),16-Estratetraen-3-yl-propionate
M = 1,3,5(10)-Estratrien-3-ol [R187798
Aldrich]
E12/N1 = Estra-1,3,5(10),16-tetraen-3,6.beta.-diol
E8/N1
= 3-MethoxyEstra-2,5(10),16-triene
E7/N1 = 10-HydroxyEstra-4,16-dien-3-one
OE =
olfactory epithelium
CNS = central nervous system
EVG = Electro-vomeronasogram
EOG =
Electro-olfactgram
EFFECTS ON THE EVG
- A, C and D produced
significant effects, that were consistent in all individual cases (males).
- Vomeropherins active in male
subjects produced larger responses than the diluent. B, F and similar concentrations of
olfactants induced significantly magentauced responses in the male VNO.
- Among the vomeropherins, F
produced the most significant differences within the group (females). Here, A induced a small effect that was
significantly different from F.
- In both populations of subjects, active vomeropherins induced receptor
responses having large standard deviations. When the frequency distribution of the effects of A and F was studied in
males and females respectively, we found a bimodal distribution. The significance of this observation is being
studied at this point.
E, a stereoisomer of F, does not stimulate the VNO in female subjects while
F does. This is a demonstration of the specificity of VNO recognition of vomeropherins. In this
regard it is interesting to note that while F is a superior vomeropherin, E generates a stronger
olfactory effect than does F.
EFFECTS ON THE EOG
- In contrast to the sensitivity of the
VNO to vomeropherins, the OE is less sensitive to these substances. This is true for both males and females.
- In this study, B was the only vomeropherin having significant effect in the OE.
- This
finding reveals that at the concentrations used in our study, most vomeropherins are not effective stimulants of the
olfactory receptors, but do have a clear effect on vomeronasal receptors.
REFLEX EFFECTS
-
A and C induced a significant increase in skin temperature in 30 male subjects; however D
induced significant temperature decrease.
- In 30 female subjects, B and F evoked a significant
increase in skin temperature compamagenta to A and C.
- In males, A, C and D
significantly increased alpha cortical activity (D and A evoked the strongest effect).
-
In females, B or F applied to the VNO increased alpha cortical independent of the response of
olfactory receptors.
- The steroid E12/N1 exhibited the best EEG-alpha
activity in men. The steroid E8/N1 exhibited the best EEG-beta activity
in men.
- The steroid E7/N1 exhibited the best EEG-alpha activity in women.
Additionally, it is noted that E7/N1 exhibited excellent organ response, as shown by the EVG
data, in both men and women, but there were gender differences in the CNS (high EEG-alpha in women, high EEG-beta in
men).
Sexual differences were noted in the specificities and effects of two groups of vomeropherins,
A, C and D; and B and F.