Androstanone?

[Archetypical Hybrid (HEC)]

AndrostAnone

was hypothesized to be more biologically active at the human female VNO versus androstenone, due to structure

activity relationship observations.

I do know that androstAnone is a component in - my analysis of the

mix did prove this much. Quantitative analysis not performed.

[bronzie]

AndrostAnone was hypothesized to be more biologically active at the human female VNO versus androstenone, due

to structure activitiy relationship observations.

VNO is a non functioning organ, therefore I

believe that the hypothsis you mentioned above is incorrect.

[Archetypical Hybrid (HEC)]

VNO is a

non functioning organ, therefore I believe that the hypothsis you mentioned above is incorrect

Au

Contraire! I'd like to see your evidence bronzi boy.. While the VNO is less of a driving force in higher

mammels (such as are we) it nontheless influences behavior - this is common knowledge.

There is also the fact

that physiological reaction (behavior) to a vomeropherin (such as in Androstadienone [or A1]) strongly correlates

its activity at the VNO. Same story with Estratetraenol.

AndrostAnone is known to evoke a

stronger response in the human female VNO then does androstenone (thus proving my original theory correct).

See

for yourself:


AndrostAnone is the first bar

shown (5α-androstan-3-one)


Androstenone (-none) is the

forth one listed (5α-androst-16-en-3-one)


Androstadienone is the fifth one listed

(androsta-4,16-en-3-one)



P.S. There is also

the fact that androstAnone is far more volatile than androstenone. AndrostAnone's MP is 103˚C,

whereas androstenone's MP is 145˚C (according to the Sigma-Aldrich catalog). Thus, the vapor

pressure is higher and hence it evaporates into the air (where pheromones are active) much moreso than

androstenone.

[Andras]

˚[/SIZE]C,

whereas androstenone's MP is 145˚C (according to the Sigma-Aldrich catalog). Thus, the vapor

pressure is higher and hence it evaporates into the air (where pheromones are active) much moreso than

androstenone.

I think you mean... basically, it's going to shoot out of you a lot faster and

hence more direct/radialogically (aura). very good P.S. since the reactions are making sense to the point.

[Bubba]

P.S. There is also the fact that androstAnone is far more volatile than androstenone. AndrostAnone's MP is

103žC, whereas androstenone's MP is 145žC (according to the Sigma-Aldrich catalog).

Thus, the vapor pressure is higher and hence it evaporates into the air (where pheromones are active) much moreso

than androstenone.

I can't find it in the catalog under either 5-ALPHA-ANDROSTAN-3-ONE or

androstanone. What is the catalog number?

[Archetypical Hybrid (HEC)]

It was an old

catalog - Sigma has discontinued androstanone. There are currently only two suppliers worldwide for the

raw-material.

[jvkohl]

AndrostAnone was hypothesized to be more biologically active at the human female VNO versus androstenone, due

to structure activity relationship observations.

"...there is now overwhelming evidence that the

vomeronasal organ (VNO) is not functional in human adults (Wysocki and Preti 2004)."
Quoted from: Penn, D. (2006)

Chemical Communication.

JVK

[Archetypical Hybrid (HEC)]

You're wrong

JVK, and so are Wysocki and Preti